Cardiac MRI showed functional parameters, such as LVEF. Cardiac FAP volume was determined by PET imaging and the area of injury was defined by SPECT imaging. In their study, the German researchers showed that the activity of fibroblast cells was strongly correlated with tissue characteristics from cardiac MRI, a standard test for measuring LVEF.Īll 35 patients underwent Ga-68 FAPI-46 PET/CT scans, as well as standard perfusion SPECT and cardiac MRI within 11 days after a heart attack. Moreover, fibroblast cells have been shown to be highly active during this molecular process. LVEF is typically reduced in patients after heart attack as the heart muscle undergoes "remodeling" in response to injury. Left ventricular ejection fraction (LVEF) is the measurement of how much blood is being pumped out of the left ventricle of the heart with each contraction. "The early PET signal exhibited a stronger correlation to at follow-up, suggesting a relationship between the extent of fibroblast activation and worse ventricle remodeling," said nuclear cardiologist Dr. Johanna Diekmann during a presentation before the award announcement. The team found that the FAPI-PET signal in injured heart muscle predicted heart dysfunction in patients more than four months later. Using a gallium-68-labeled (Ga-68) radiotracer designed to bind to fibroblast cells (Ga-68 FAPI-46), a group from Hannover Medical School in Germany performed fibroblast-activation protein inhibitor (FAPI)-PET imaging in 35 patients several days after they experienced a heart attack. ![]() ![]() J- PET imaging that reveals poor outcomes in patients after a heart attack has won Image of the Year honors at this year's Society of Nuclear Medicine and Molecular Imaging (SNMMI) annual meeting. SNMMI Image of the Year predicts poor outcomes after heart attack By Will Morton, staff writer
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